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5.4 Anatomical and technical determinants of ctDCS efficacy Despite the use of standardized protocolstypically positioning the active electrode 12 cm below the inion and 1 cm medial to the mastoids to target the cerebellar vermisreported outcomes remain inconsistent: some studies demonstrate robust neuromodulatory effects, whereas others do not detect significant changes

Although none of the NIK inhibitors have entered clinical trials to date, the recent preclinical studies underscore promising progress

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