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These doses fall within the effective and widely used ranges in murine models, where TMZ at 20 mg/kg has repeatedly demonstrated antioxidant and anti-inflammatory efficacy, and probiotic doses between 10 6 and 10 9 CFU/mouse/day are considered adequate to induce functional gastrointestinal effects (Jain et al

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Firstly, GA inhibited vascular calcification by blocking the BMP2-Smad1/5/8 signaling pathway.In vascular smooth muscle cells (VSMCs) induced by inorganic phosphate (Pi), GA inhibited vascular calcification by interfering with the osteogenic signaling pathway through suppressing BMP2 upregulation and Smad1/5/8 phosphorylation (Kee et al., 2014)

Cell Death Differ 20(1):117129