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Approximately 1% of molecular oxygen undergoes partial reduction at complexes I and III, generating superoxide (O 2 ) that partitions into the mitochondrial matrix (Complex I) or intermembrane space (Complex III) (Okoye et al., 2023

Schmiedel BJ, Singh D, Madrigal A, Valdovino-Gonzalez AG, White BM, Zapardiel-Gonzalo J, et al

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A randomised, double-blind clinical study has provided scientific validation of green coffee bean functionality and recommended the safety of supplementation in healthy individuals