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This is known to occur in tumors where the fast-growing cells often grow beyond the blood supply that would normally provide oxygen.A normal cell would undergo apoptosis under these conditions, but because cancer cells often have their apoptotic mechanisms inhibited they continue to survive with little or no oxygen available

i.p.) prior to injection of the metabolic inhibitor 3-nitropropionic acid (3-NPA) in adult Sprague Dawley rats attenuated the 3-NPA induced increase in expression of the uncoupling protein UCP-2 and dopamine D(1) receptor genes in striatum that were upregulated in response to impaired metabolism [87]

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Thus, a large amount of hemolymph might be accessible with relatively little effort to penetrate the cuticle

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