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In addition, FTH1 converts Fe 2+ to Fe 3+ , which attenuates lipid peroxidation caused by high levels of free iron and inhibits ferroptosis

Tirzepatide causes thyroid C-cell tumors in rats, and although its unknown whether tirzepatide causes thyroid C-cell tumors in humans, it is contraindicated in patients with a personal or family history of MTC or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)