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Grady C, Bedarida G, Sinaii N et al

A recent review has summarised studies focusing on metabolic patterns related to metformin response in pre-diabetes and diabetes (Table 1

Interestingly, a small trial in 30 premenopausal women found that daily multivitamin supplementation for ten weeks did not improve overall mood, but when the supplement also contained 7 mg/day of zinc (RDA=8 mg/day), the authors noted significant improvements in two components of POMS: the anger-hostility and the depression-dejection scores (140)

FEMS Microbiol Rev 31:293310

Glutamate taken up by perisynaptic astrocytes is then converted to glutamine via glutamine synthetase (Danbolt, 2001)