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Later fibrotic skin lesions become less inflammatory, avascular with thickened blood vessel walls and narrow lumens, and collagen bundles get thick, compact, and highly eosinophilic with few or absent sweat glands (Figure 2B)

Subject Model Characteristics: The species, age, weight, and overall health status of your research subjects are paramount

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Effect of angiotensin-converting-enzyme (ACE) inhibitor trandolapril on human diabetic neuropathy: Randomised double-blind controlled trial