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Lim D, Kyozuka K, Gragnaniello G, Carafoli E, Santella L

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Abbreviations ARE: Antioxidant response element CAT: Catalase Cys: Cysteine FFAR: Free fatty acid receptor GSH: Glutathione reduced GPR: G protein-coupled receptor GST: Glutathione-S-transferases Glu: Glutamate HO-1: Heme oxygenase-1 H 2 O 2 : Hydrogen peroxide Keap-1: Kelch-like ECH-associated protein 1 MAPK: Mitogen-activated protein kinase NF-B: Nuclear factor kappa beta Nrf2: Nuclear factor-erythroid 2 related factor 2 ROS: Reactive oxygen species SOD: Superoxide dismutase STAT3: Signal transducer and activator of transcription 3 References Hill C, Guarner F, Reid G, Gibson GR, Merenstein DJ, Pot B, Morelli L, Canani RB, Flint HJ, Salminen S, Calder PC, Sanders ME (2014) Expert consensus document

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Blocking TDO and IDO1 to improve the efficacy of cancer immunotherapy would be complementary