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It is a spectrum of biochemical vulnerability

In situ riboflavin fortification of different kefir-like cereal-based beverages using selected Andean LAB strains

An accumulation of TCA intermediates may subsequently have an impact on the macrophage phenotype, e.g., by contributing to a pro-inflammatory phenotype [e.g., as shown for succinate (Tannahill et al., 2013) and oxaloacetate ( 4.2.1 TCA intermediate accumulation in M1 and trained macrophages More specifically, increased glutamine uptake in LPS-stimulated macrophages triggered the accumulation of succinate, which stabilized HIF1 and thereby increased the expression of the inflammatory mediator IL-1 (Tannahill et al., 2013)

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It helps modulate the immune response, providing support during infections and illnesses