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Fifth, interpretation must be iterative and culturally embedded: mechanistic and toxicology findings should be mapped back onto ethnographic data by comparing experimental doses and preparation conditions to traditional practice, interpreting mechanistic signatures in light of preparation-dependent chemistry and reported community outcomes, and validating interpretations through participatory workshops with knowledge holders

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Beyond its role in oxidative stress, SIRT1 also regulates the circadian clock, a system increasingly recognized as vulnerable to dysfunction in neurodegenerative disorders [52]