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[27] A recent case series of 101 adults with asthma reported that macrolides (mostly azithromycin) and tetracyclines, either separately or in combination, appeared to be dramatically efficacious in a subgroup of "difficult-to-treat" (i.e., not necessarily refractory to high-dose inhaled corticosteroids but who did not take them) patients with severe asthma, many of whom also had the "overlap syndrome" (asthma and COPD)

Comet assay for DNA damage Cells in culture were untreated (DMSO, control) or treated with R001 at the indicated concentrations for 24 h, or in the case of H 2 O 2 (400 M), cells were treated for 1 h

Vitamin B12 is involved in the metabolism of every cell of the human body, especially affecting DNA synthesis and regulation, but also fatty acid synthesis and energy production

15 Arterial thrombosis causes reduced blood flow (ischemia), resulting in reduced oxygen and nutrient delivery and ischemic tissue damage

Cytokines affect the magnitude of inflammation or immune responses