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doi: 10.1210/jcem-58-3-544

-Plant 50 , 166175 (2014)

When portal pressure increases, the portal venous system becomes dilated and forms collateral connections to the systemic venous flow (Figure 50-8), leading to portosystemic shunting

Elevated methylation in these regions has been consistently observed in individuals with MDD and heightened suicide risk, implicating the silencing of genes critical for stress adaptation and emotional regulation (242, 245)