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Kitazawa et al., 2005)

(2019) 28:211123.e6

Accumulating evidence suggests that mtDNA mutations are not merely passive byproducts of tumorigenesis, but instead actively reshape cellular metabolism [179, 180], redox balance [181], immune interactions [182, 183], chemotherapy resistance [80, 184], metastatic potential [33] and apoptotic sensitivity [185]

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