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The Metabolism of Acetaminophen and the Synthesis of Glutathione Download Scientific Diagram GSH reduces NAPQI, the metabolite responsible for hepatotoxicity in acetaminophen toxicity. Toxic doses increase oxidation into NAPQI, overwhelming glutathione. How does ethanol interfere with acetaminophen metabolism? Image: https: t.co 6EY9dIwLXY PharmGKB summary: Pathways of acetaminophen metabolism at the therapeutic versus toxic doses PMC Acetaminophen overdose resulting in massive hepatic necrosis. Note the scant residual periportal hepatocytes. #liverpath #hepatology Nishith Revappala Concept explained from Simplify Rx Instagram

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