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1) A key feature of early sepsis is hypoxia

Similarly to what was observed in the case of GSAO and CAO ( S-nitrosoglutathione S -nitrosoglutathione (GSNO) is the S -nitrosated derivative of GSH and is thought to be a critical mediator of the downstream signaling effects of NO ( S -nitrosation or S -glutathiolation (Hogg et al., 1997

To achieve this, we need a better understanding of actual sites of mechanical impact within the eye and identification of mechanical stressors (tensile strain, shear flow, compression etc.) that are sensed by cells in both the anterior and the posterior eye