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Abstract Organ fibrosis is a pathological process characterized by the inability of normal tissue cells to regenerate sufficiently to meet the dynamic repair demands of chronic injury, resulting in excessive extracellular matrix deposition and ultimately leading to organ dysfunction

10.1111/1750-3841.15038 J

doi: 10.1016/j.toxicon.2016.04.036, 85

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Other times it is because of impaired nutrient digestion/absorption in the gastrointestinal tract