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However, oxidants released by harmful gases (e.g., smoke, dust) induce oxidative inactivation of AATwith oxidative stress further exacerbating this inactivation ( 6 Metabolic reprogramming in COPD experimental models 6.1 Introduction to metabolic reprogramming The process by which cells alter their metabolic pathways to meet their bioenergetic, biosynthetic, and redox needs in response to adverse environments such as hypoxia and nutrient deficiency is termed metabolic reprogramming ( Table 1

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