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Partay LB, Jedlovszky P, Brovchenko I, Oleinikova A (2007)

Acta 182 (56), 917923 (2015)

Molecular engineering and the exploration of novel mechanisms Enhancing the cellular permeability of PROTACs and circumventing efflux pump-mediated resistance are critical determinants of their in vivo efficacy

These properties can be influenced through the kinetic interaction conditions between metal ions and reducing agents, by modifying synthesis methods, characteristics of the reducing agents, and the use of stabilizers