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Polyunsaturated fatty acids improve exercise capacity in chronic obstructive pulmonary disease

Rishniw and Brown warn that such breeds as the CKCS "likely require breed-specific reference intervals for LVIDDN to correctly identify left ventricular enlargement." They also point out: "For example, if a dog has a LVIDDN that consistently oscillates around 1.3 (within 0.1 units), an increase to 1.6 could indicate left ventricular enlargement for that dog, despite being within the population-based reference interval." Well, in the EPIC Study, due to the lack of any inclusion criteria relevant to heart enlargement, the peers have every reason to justifiably doubt its results

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It is important to note, that not only the increased production of ROS and RNS but also the decline in the efficiency of antioxidant systems with age leads to oxidative stress (Liguori et al., 2018)

Biopharmaceutical benchmarks 2018