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EAD indicated metabolite-specific fragments at m/z 311.0610, m/z 324.0706, m/z 342.0796, m/z 370.0737 and m/z 442.0980

[5] [8] [12] When the need for ribose 5-phosphate is much greater than that for NADPH When significantly more ribose 5-phosphate than NADPH is required, as in rapidly dividing cells with high rates of nucleotide synthesis, precursors of DNA, the oxidative phase of the pentose phosphate pathway is bypassed , and NADPH is not produced

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Several different mechanisms have been suggested to contribute to TJ alterations and BBB disruption in experimental stroke models