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Additionally, SNRIs such as duloxetine exert their analgesic effect by enhancing serotonin (5-HT) and norepinephrine (NE)-mediated descending inhibitory systems in the spinal cord (Obata, 2017)

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First isolated in the 1970s from the cerebral venous blood of sleeping rabbits, DSIP (Delta Sleep-Inducing Peptide) is a naturally occurring nonapeptide whose biology has fascinated and puzzled neuroscientists for half a century

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