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This can lead to the activation of endogenous toll-like receptors (TLRs), resulting in the release of inflammatory cytokines and type I interferon, or it may ultimately cause cell lysis through cytotoxic effects of immune cells, thereby releasing damage-associated molecular patterns (DAMPs)

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1063,1064 Therefore, limiting lipid elevation may have anti-tumor effects, but conclusive data from more preclinical models are needed

PubMed Central , Methods in Molecular Biology (Clifton, N.J.) , vol