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Jansen et al., 2018) fall within the human range of 8781,170 mg/day

doi: 10.2147/JIR.S396049 155 VerheijdenKATSonneveldRBakker-Van BebberM

Normally, Tyr-274 of this enzyme links to a specific phosphate in the DNA via a 3 1 - phosphodiester bond W topoisomerase forms a covalent protein-DNA intermediate at recognition sites in duplex DNA