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Serotonin, in turn, has been found to influence transcription of the CLOCK genes in a preclinical model (181, 182)

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Third, clinical efforts should include establishing multicenter FRDA biobanks to validate associations between ferroptosis biomarkers (such as ACSL4 and mitochondrial iron content) and clinical measures including SARA ataxia scores and left ventricular ejection fraction, and conducting combination trials of ferroptosis inhibitors with ironsulfur cluster metabolism regulators to evaluate synergistic improvement in neurologic and cardiac function

there are some scholarly articleso n this published in sweeden in late 90s that confirmed this existence in mercury exposed individuals