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Although the potential effects of VD on the prevention and treatment of PD are e not clear, there is much evidence associated with its neuroprotective effects by reducing excitotoxicity in PD

TLR4: toll-like receptor 4

Thus, GABA from reactive astrocytes diminishes the spike probability of the perforant-path-to-dentate-granule-cell synapse, leading to impairment in synaptic plasticity and memory function

Zheng J, Zeng Q, Zhang R, Xing D, Zhang T

however, Phe296 in DnrK can be rotated towards the channel thus blocking solvent access by insertion of a serine residue between Phe296 and Thr297, which mimics the Ser301 in RdmB (Fig