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Patients who receive a single dose of cisplatin may suffer from reversible kidney injury, while large doses or multiple courses of treatment may cause irreversible renal failure [9]

3 The UK National Institute for Health and Care Excellence (NICE) states that a cut-off of 200 ng/l identifies 97% of people with B12 deficiency, and a level below 100 ng/l is usually accompanied by metabolic or clinical evidence of B12 deficiency

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Unlike some medications with circadian-dependent metabolism, B12 absorption mechanisms function consistently throughout the 24-hour cycle

Kerr et al, 2012), where the cisplatin (CDDP) insult is delivered to prepubertal mice which have a high primordial follicle reserve