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10.1016/j.intimp.2024.112893 31 ChenN.XieQ

Sirtuins and type 2 diabetes: role in inflammation, oxidative stress, and mitochondrial function

We conclude that the increased synthesis and use of ketone bodies as ancillary fuel during periods of deficient food supply and low insulin levels causes oxidative stress in the mitochondria and that the latter initiates a protective (hormetic) response which allows cells to cope with increased oxidative stress and lower energy availability