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Epitalon is a synthetic tetrapeptide with the sequence Ala-Glu-Asp-Gly (AEDG), developed as a synthetic analogue of the active fraction of the pineal polypeptide epithalamin

Cause progressive microtrauma that manifests as localized induration, reduced vascular perfusion, and altered lymphatic drainage

As regulatory decisions evolve, access may change

Using a 27 G needle attached to a 5 mL Luer-lock syringe, multiple longitudinal and oblique micropunctures depending on plaque size (typically 4 tunnels /cm of fibrotic tissue) are created throughout the plaque

Internal blockers include oral medications or dietary supplements