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This would support either camp of thought around whether PD pathology is driven by a proteinopathy (toxic accrual of S aggregates gain of function) or a proteinopenia (loss of S native function)

PubMed Mihovilovic, K., Sever, M., Zoricic, I., et al

These are the same pathways cancer cells exploit to grow and spread

For example, Liu and collaborators observed similar effects to those described in HCC, but in pancreatic cancer cells (Liu et al., 2018 [19])

This approval represents the first FDA-approved drug specifically targeting mitochondrial function, establishing regulatory precedent for the mitochondrial dysfunction pathway in aging and neurodegeneration