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Knockout mice models for T1R2/T1R3 (Zhao et al., 2003) and its downstream molecules such as gustducin, PLC2 (Zhang et al., 2003), IP3R (Hisatsune et al., 2007), and TRMP5 (Zhang et al., 2003), verified their functional roles in sweet taste transduction, but residual responses to caloric sugars and not to non-caloric sweeteners (Damak et al., 2003) called for alternative mechanisms responsible for oral-mediated sweet gustation (Glendinning et al., 2015, 2017

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