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Sperm mitochondrial DNA copy numbers in normal and abnormal semen analysis: a systematic review and meta-analysis

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According to fetal programming (Parrettini, Caroli, & Torlone, 2020), unfavourable factors such maternal starvation during early organogenesis can permanently change organ and organ system anatomy

Through a variety of mechanisms, including the regulation of cell behaviors like proliferation, differentiation, increased maturation and apoptosis, autophagy, and epithelial-mesenchymal transition (EMT), as well as the modulation of interactions between cells and their microenvironment, such as the suppression of inflammation, the immune system, angiogenesis, and anti-oxidants, vitamin D can control tumor cells (64)