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GSTs have emerged as a promising therapeutic target because specific isozymes are overexpressed in a wide variety of tumors and may play a role in the etiology of other diseases, including neurodegenerative diseases, multiple sclerosis, and asthma

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Indeed, computer model simulations demonstrate that weight-dependent heterosynaptic plasticity can robustly prevent runaway dynamics of synaptic weights and runaway activity of model neurons subject to widely different patterns of activity and equipped with widely different plasticity rules (Chen et al., 2016

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