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But the jump from C57BL/6 mice to humans involves differences in metabolic rate, NNMT tissue distribution, adipose tissue physiology, and drug metabolism that preclinical data cannot address

An open-label trial used VEGF165 gene transfer as an intra-muscular injection in the ischemic thigh in patients with critical ischemia with/without DM

Data availability Plasmids described in this study were deposited to the Addgene repository under accession numbers 257812257815

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