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No significant difference was observed between the healthy control compared to 5-ASA enema (asacol) and oral (mesalazine)-treated groups, and oral HAEA at the dosage of 600 mg/kg and HAEA gel 10% enema treated groups ( P = 0.320, 0.291, 0.511, 0.501 for epithelium, and 0.172, 0.425, 0.333, 0.339 for submucosa, and 0.633, 0.794, 0.907, and 0.633 for muscularis mucosa, respectively)

Peripheral infiltrates were predominantly observed in the nerve conduits during the early phase, which gradually dispersed and reduced size

The latter accumulate in cell nuclei, and repress CLK/CYC activators, leading to suppression of per and tim transcription

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Includes plant placenta, white tomato, astaxanthin and amino acids for antioxidant protection and skin repair