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The metabolite mixes used here were the same as the metabolites that correlated with the acute and sustained increases of FMD observed in humans

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In a study conducted on transgenic mice expressing extremely low levels of A1AT and exhibiting to daily cigarette smoke for up to 6 months, the use of augmentation treatment (Prolastin 20 mg every 48 hours) resulted in a significant reduction in lavage neutrophils and macrophages, approximately of 75% and 50% respectively after 6 months

10.1016/j.phrs.2020.105371 85 SunY.PuL