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A Systematic Review with Meta-Analysis

In HBx-transgenic mice, liver regeneration capacity is reduced following PHx, as HBx disrupts the cell cycle by inhibiting the G1/S phase transition and altering the expression of key regulators such as p21 and PCNA

The anti-folateanti-cancer chemotherapeutic drug methotrexate (Table 1) is used clinically for curing multiple cancers, especially acute leukemia, despite its serious side effects