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At a pre-symptomatic stage, the deletion of Trkb in iSPNs leads to the upregulation of Gsto2 , increasing DA levels by controlling AA homeostasis and impacting energy metabolism, leading to progressive motor dysfunctions

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S15B, C and Fig

It has previously been shown that BAP transcripts are induced by a number of biotic and abiotic stimuli and that overexpression of BAP1 and BON1 delays HR induced by two avirulent strains of the bacterium Pseudomonas syringae and cell death induced by the ROS-generating herbicide paraquat [172]

Therefore, Bnip3 might mediate parkin translocation to mitochondria through the Tom protein complex