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Self-medication or long-term unsupervised use is not recommended

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People who follow vegetarian or vegan diets may be at higher risk of inadequate intake and may consider fortified foods or supplements after consulting a healthcare provider

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Consistent with these observations, in vivo metabolic profiling in rats has revealed that EC undergoes extensive mono- and di-methylation, often followed by subsequent glucuronidation or sulfation, resulting in the formation of structurally diverse phase II conjugates (Shang et al., 2017)