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Systemic metabolic alterations and their relationship to neuropsychiatric symptomatology PAIS, including long COVID, as well as CFS and IMD, share the characteristic of systemic metabolic disturbances, which may be a sign of underlying multi-organ inflammation and exhaustion [31], and consequently may contribute to neuropsychiatric symptomatology, as many metabolites can cross the bloodbrain barrier (BBB) [30, 58] (e.g., short chain fatty acids (SCFAs) derived from the gut microbiota such as acetate [40], amino acids such as tryptophan [52] and also carnitine/acetylcarnitine can cross the BBB via transporters [59])

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In the early 20th century, Franz (1904) elucidated the mechanisms underlying FA degradation by successive cyclic removal of two carbon units at a time, which subsequently initiated further studies on FAO (Schlaepfer and Joshi, 2020)

administration, approximately 76% of the levocarnitine dose was excreted in the urine during the 0-24h interval

& Sugden, M