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Forty rats were divided into 4 groups (n = 6/group): caffeine 300 mg/kg group (CG), taxifolin 50 mg/kg + caffeine 300 mg/kg group (TCG), 2 mg/kg diazepam + 300 mg/kg caffeine group (DCG), and a healthy group (HG)

Moreover, the combination therapy was partly abrogated by altering the expression of NICD (Notch intracellular domain)

Then, the filtered datasets were compared to the Omit LaccID condition, using a P -value cutoff of 0.01 and an FDR of 5% for monocultures and 10% for cocultures (Supplementary Table 2 and Supplementary Figs

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XJB-5-131 has a high affinity for TECs and reduces I/R-induced renal injury in mice by downregulating the expression of ACSL4 to inhibit ferroptosis