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When the copper ion content is high in liver cells, the ATOX1 binds with excess copper ions and transports them to the N-terminal metal-binding region of ATP7B, which is then excreted through the bile duct membrane

Hwang, C., Sinskey, A.J

Such approaches may overcome the limitations of methods such as the spectral difference method, which assume the homogeneity of an image medium 73, 74