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1861-A BEMNIFOSBUVIR AND RUZASVIR ARE POTENT HCV DAAS WITH FAVORABLE ANTIVIRAL PROFILES AGAINST MAJOR HCV NS5A AND NS5B RAVS SUPPORTING USE IN COMBINATION Qi Huang, Steven Good, Dawei Cai, Nancy Agrawal and Jean-Pierre Sommadossi, Atea Pharmaceuticals, Inc

Necroptosis, a regulated form of cell death primarily dependent on receptor-interacting protein kinase 3 and mixed lineage kinase domain-like, is characterized by widespread cytoplasm and organelle swelling, plasma membrane rupture and release of cell components into the microenvironment (118)

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Activation of XKR8 by caspase-3 triggers NET formation The signaling cascades that orchestrate NET formation are extremely intricate and not yet fully understood 15,26