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doi: 10.1152/ajpcell.00130.2023 33 Van der StedeTVan de LoockATurielGHansenCTamariz-EllemannAUllrichMet al

340 Understanding the role of insulin signaling and insulin resistance in peripheral nerves is essential for developing targeted therapies for DPN

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Specifically, the irontransferrin complex enters cells via transferrin receptor 1 (TFR1)-mediated endocytosis, forming endosomes in which ferric iron (Fe + ) is reduced to Fe + by six-transmembrane epithelial antigen of prostate 3 (STEAP3), and then transported into the LIP by divalent metal transporter 1 (DMT1)