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In some cases, the underlying cause may remain unknown

3 linked pagesOpen original pubmed-heffernan-aod9604-2001 AOD-9604 Clinical Trial Registry Entries: ClinicalTrials.gov ClinicalTrials.gov / U.S

Our improved understanding of the complex biological regulation of appetite, metabolism and body weight, involving co-ordinated responses between peripheral tissues and central appetite-regulating centres, has resulted in the availability of nine Food and Drug Administration (FDA) (liraglutide, semaglutide, tirzepatide, orlistat, phentermine, phentermine/topiramate, bupropion-naltrexone, setmelanotide, and metreleptin), and seven European Medicine Agency (EMA) (excluding phentermine and phentermine/topiramate), approved AOMs

We also assessed hippocampus-dependent memory by NORT, and STZ-treated mice showed a lower DI values than wild-type (WT) mice (Figs

It is important to note that it is not yet approved for general medical use