The Inhibitory Effect of Glutathione on the Change of Apoptosis Markers Genes by H 2 O 2 is Reversed by ZnPP in RAW 264.7 Cells To further investigate the molecular mechanisms of the apoptosis-protective effect of glutathione and the role of HO-1, we examined the effects of glutathione and ZnPP on H 2 O 2 -induced changes of the apoptosis-regulated gene expression
Shan Y, Yang F, Tang Z, Bi C, Sun S, Zhang Y, et al
(57) induced senescence in rat adrenal pheochromocytoma cell lines and mouse embryonic fibroblast lines via the use of rapamycin and etoposide, followed by treatment with peanut skin PCs
Cell 26 , 114 (2007)
Tuft cells are chemosensory cells detect microbial or parasitic signals and secrete interleukin-25 (IL-25), which activates group 2 innate lymphoid cells (ILC2s) ( Clostridioides difficile infection (CDI) colitis models, IL-25 expression is suppressed, and IL-25 supplementation restores eosinophil numbers and reduces mucosal injurydespite no changes in bacterial burden or toxin levels ( Furthermore, eosinophils can secrete anti-inflammatory and pro-resolving mediatorsfor example, they are a source of specialized pro-resolving mediators (SPMs) like maresins and protectins ( In summary, the role of eosinophils in the intestine has expanded from a narrow focus on parasite defense to a broader appreciation of their part in immune modulation, host-microbiome interactions, and tissue homeostasis
