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Glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), amylin, glucagon and ghrelin all proved to be tractable drug targets, and mapping how they regulate hunger and energy use produced today's obesity drugs (PMID 34067710)

10.1172/JCI20039 J Clin Investig

(7) I A Vinogradova 1, A V Bukalev, M A Zabezhinski, A V Semenchenko, V Kh Khavinson, and V N Anisimov (2007) Effect of Ala-Glu-Asp-Gly peptide on life span and development of spontaneous tumors in female rats exposed to different illumination regimes Bulletin of Experimental Biology and Medicine, 2007 Dec, Volume 144 (Issue 6), Pages 825-30

Excessive ROS production is a major pathological mechanism of neurodegenerative diseases, and IF protects neurons by activating the Nrf2 signaling pathway, increasing the expression of antioxidant enzymes such as superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), and reducing ROS accumulation (27)

The leakage of MSCs at the implanted site also hinders its application