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Hypoxia also induces changes in [Ca 2+ ] i that conduces to the activation of protein kinases and phosphatases along with Ca 2+ -dependent signaling pathways involved in hypoxia gene expression (Seta et al., 2004)

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70 The reproducibility of functional MRI data has shown to be limited and this may be related to variables that systematically alter pain perception and concomitant brain activity in each individual pain patient such as mood, painful experiences, social support/distraction and expectations of pain intensity

Fusion-mediated transport is a critical mechanism that allows exosomes to bypass endosomal degradation, ensuring the intact delivery of their cargo across the BBB