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Furthermore, signs of gastrointestinal toxicity (nausea, vomiting, constipation, diarrhea, abdominal pain) have been observed following oral iron supplementation at different dosages in humans [55]

Further synthetic strategies should consider incorporating substituents to increase the degree of nucleophilic attack at the sulfur in selenenyl sulfide

The limits of passive targeting techniques are highlighted by thorough assessments of nanoparticle delivery efficiency, which have revealed that, on average, less than 1% of the injected nanoparticle dosage penetrates solid tumors [11, 12]

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But the mechanism here is plausible enough to warrant attention in human studies too