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Research has shown that buffer solutions at pH 3 to 5 can reduce deamidation, slow oxidation, and protect disulfide bridges from exchange reactions

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doi: 10.1126/SCIIMMUNOL.AAI7793 23 TooleyJEVudattuNChoiJCotsapasCDevineLRaddassiKet al

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We believed that maintaining the data completeness criteria threshold of at least 70 percent for 4 years provided adequate time for individual MIPS eligible clinicians, groups, virtual groups, and APM Entities to adjust to the increase that went into effect at the onset of the COVID-19 public health emergency and account for the implications the COVID-19 pandemic had on the healthcare system