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In contrast, under oxidative stress conditions, ubiquitin ligase activity is blocked by modifying the cysteine residues in Keap1, thereby stabilizing and activating (Noguchi et al., 2018), stable NRF2 then translocates into the nucleus, binds to antioxidant response elements in the gene promoter region and regulates the transcription of a range of target genes involved in antioxidant defense and cellular redox maintenance (Ooi et al., 2018

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Glutathione crosses the blood-brain barrier in its liposomal form, where it protects neurons from free radical accumulation and supports mitochondrial function

Long-term clinical trials, including one that lasted four years, found no serious safety concerns at these levels.7 Most people tolerate ALA well, but some mild side effects can occur, especially at higher doses: Digestive issues like nausea, bloating, or stomach upset Skin reactions, including rash or itching Low blood sugar, especially when taken with diabetes medications These side effects are usually temporary and mild, but they appear more frequently at doses of 1,200mg/day or higher.3 4 Medication interactions ALA may interact with several medications and should be used with caution in these cases:39 Diabetes medications (e.g., insulin, metformin) ALA can help lower blood glucose, which may enhance the effects of diabetes drugs and increase the risk of hypoglycemia